Experimental transmission of Alzheimer’s disease lesions

Alzheimer’s disease is a major dementia that affects nearly one million people in France. It is associated with the presence of two major lesions: amyloid-β protein deposits and the accumulation of abnormal TO proteins in neurons. The accumulation of these abnormal toe proteins is strongly associated with the cognitive impairments that characterize the disease. Studies based on post-mortem observations of human brains have concluded that accidental administration of compounds contaminated with amyloid-సమయంలో during medical-surgical procedures may induce amyloid-β pathology (80 cases described worldwide). One of the difficulties in studying the transmission of amyloid-β / tau lesions in humans is the long delay (several decades) between the potential medical-surgical procedure and the onset of pathology.

Scientists say that in addition to amyloid-β pathologies, Tou pathologies are very close to those of the brain (from humans to non-human primates (mouse lemurs), including the brain environment). The transmitted lesions spread to the entire brain to colonize. This transmission is related to the form of memory problems.

30 years ago, several studies suggested that mutations in various proteins may trigger Alzheimer’s disease lesions in animal models. This new study highlights the second biological mechanism that triggers all lesions of Alzheimer’s disease and causes their spread in the brain, not genetic. It emphasizes the need for systematic adherence of individuals who have experienced medical-surgical procedures associated with the risk of transmission of amyloid-β and tau proteins.

Intracerebral vaccines extracted from the brain of patients with Alzheimer’s disease into murine lemurs induce microscopic lesions typical of Alzheimer’s disease (amyloidosis and typhoid) and spread from the focal point of the vaccine to the entire brain. These changes are related to the appearance of cognitive disorders. These data suggest that the biological, non-genetic mechanisms involved in this transmission play an important role in the biology of Alzheimer’s disease.

Learn more:
Transmission of amyloid-beta and Tou pathologies is associated with cognitive impairments in primates.
Lam, S., Petit, F., Herard, A.-S., Boluda, S., Eddarkaoui, S., Guillermier, M., The Brainbank Neuro-CEB Neuropathology Network, Beau, L., Dukecarts, C. , Haïk, S., Picq, J.-L., Dhenain, M.
Acta Neuropathologica Communications 12 October 2021
https://doi.org/10.1186/s40478-021-01266-8.

Hydrogenic transmission of β-amyloid and tofu proteins: clinical and biomedical significance for Alzheimer’s disease.
Denain m.
Bulletin of the National Academy of Medicine August 2021
https://doi.org/10.1016/j.banm.2021.04.018.