July 5, 2022

The Queens County Citizen

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Osites derived from stem cells

Osites derived from stem cells


  • Researchers have been successful in obtaining mouse oocytes from stem cells by modifying the activation of just eight genes.
  • Forcible activation of genes has made it possible to convert fluoripotent stem cells in mice into fertilized oocytes.

This could be the beginning of the fertilization revolution. Japanese researchers at the Faculty of Medical Sciences at Kyushu University have succeeded in obtaining mouse ocytes from stem cells by modifying the activation of eight genes. This technology, if validated in humans, could provide an alternative for donors to achieve assisted reproduction. The results of this discovery were presented in the journal on December 16th Nature.

Artificial insemination

The researchers were shocked to find that the stem cells were converted into oocytes. “I was at first completely disbelieving to see the mouse stem cells, the oocytes could take shape quickly and easily by introducing only a few factors.”, Nobuhiko Hamazaki, the first author of the study, was surprised. Ossite female reproduction, female equivalent to sperm. It is present in the follicles, which are in the ovaries, which are blocked in the middle of each cycle until ovulation until they reach puberty before they become the primary follicle.

Mouse fluoripotent stem cells, which can be transformed into fertilized ocytes by any cell in the body by forcibly activating genes. Mature cells are able to fertilize in vitro and “Can be fertilized in vitro and showed early development, some reaching the eight-cell stage, The researcher continues. “When cultured in the presence of other cells normally found around the oocytes, the oocyte-like cells develop structures similar to those of mature eggs, but with abnormal chromosome structure.. “All chromosomes are subjected to miosis to divide them in half and they do not work. However, they were able to fertilize.

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Good results

It is characterized by the conversion of stem cells directly into oocyte-like cells without following the same sequence of naturally occurring phases., Professor Katsuhiko Hayashi was pleased. The cytoplasm of oocyte is a very valuable unique substance. This fluid in the cell is used around the nucleus in auxiliary regenerative methods. The cytoplasm of the oocyte contains maternal proteins and RNA that are essential for the formation of life.

The cytoplasm of the oocytes is an invaluable resource for reproductive biology and medicine, and this method provides a new tool to produce in large quantities without any aggression., concluding le Pr Katsuhiko Hayashi. These processes are still very complex in humans, but these early results in mice are very promising. ”