A team of American scientists led by a researcher of Indian descent has identified a group of human genes that fight against infection with SARS-CoV-2, the virus that causes Kovid-19. Prebis Sanford Burnham Medical Discovery Institute, Professor and Director of the Summit of the program the immune system and kill pathogens. Subscriptions, according to the scientists, the virus that attacks human cells, obtained new knowledge on how to do the robbery. “We are still looking for his Achilles heel so that we can develop the right antivirals,” Chanda said in an article published in the journal Molecular Cell.
Knowing which genes can help control viral infection can go a long way in helping researchers understand the factors that affect the severity of a disease and also suggest possible treatment options.
The genes in question are linked to interferons, the body’s first-line viral fighters.
Shortly after the onset of the epidemic, doctors discovered that a weak interferon response to SARS-CoV-2 infection led to some severe cases of Kovid-19.
This knowledge led Chanda and his colleagues to investigate human genes induced by interferons, known as interferon-stimulated genes (ISGs), which work to limit infection with SARS-CoV-2.
“We found that 65 ISGs controlled SARS-CoV-2 infection, some of which inhibited the ability of the virus to enter the cells, some suppressed the production of the virus’s RNA, and inhibited the grouping of genes.
“Some ISGs have shown control over unrelated viruses, such as seasonal influenza, West Nile and HIV leading to AIDS.”
The team also identified eight ISGs that inhibit both SARS-CoV-1 and CoV-2 replication in the subcellular compartment responsible for protein packaging, suggesting that this harmful site could be exploited to eliminate infection. Viral.
“This is important information, but we still need to know more about the biology of the virus and whether genetic variation in these ISGs is related to the severity of Kovid-19,” said Laura Martin-Sancho, partner principal postdoctoral fellow. Subscription Lab.
In the next step, the researchers will examine the biology of variants of SARS-CoV-2, which develop and threaten the effectiveness of the vaccine.
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